Escape to the tropical oasis of Key West, Florida’s farthest and most fun island in the Florida Keys. Home to a spectacular beach-based bar scene and historic links to literary giants like Ernest Hemingway, Key West is an idyllic hotel, spa, and resort base. Key West’s popular Duval Street provides unrivaled nightlife, bar, and food options, while the marina provides the starting point for your next island-hopping adventure. Enjoy a stunning stay in the heart of town with a boutique hotel room in Florida's Key West. There are so many boutique hotel room options to choose from in Key West, so we've made it easier for you to browse through real hotel room photos and choose resorts by availability. Get ahead of your Florida vacation with our selection of Key West’s best boutique hotels, suites, and rooms with great five-star reviews and prices.